研究成果列表
單位名稱應用化學系教師姓名黃建智
教師分級教授專兼任專任
在校狀態離職行政職務

期刊論文(共計18筆)
序號學年度學期年度月份作者題目通訊作者作者順位期刊名稱卷數頁數關鍵字
1098120101Jiann-Jyh Huang et al.Synthesis of 2-Aryl-2H-(1,2,4)triazoloquinolin-3-one and 2-Aryl-2H-(1,2,4)- triazoloisoquinolin-3-one Derivatives from a-Chloroformylaryl-hydrazines Hydrochloride第一順位Tetrahedron66 930–934  
20991201012Jiann-Jyh Huang* et al.Synthesis and Structure–Activity Relationship of 3-O-Acylated (–)-Epigallocatechins as 5a-Reductase Inhibitors其他European Journal of Medicinal Chemistry45 6068–6076  
3098220106Jiann-Jyh Huang* et al.One-pot Ethynylation and Catalytic Desilylation in Synthesis of Mestranol and Levonorgestrel其他Tetrahedron66 4068-4072  
4099120108Jiann-Jyh Huang* et al.Discovery of Pyrrole–Indoline-2-ones as Aurora Kinase Inhibitors with Different Inhibition Profile第一順位Journal of Medicinal Chemistry53 5929–5941  
51011201210Jiann-Jyh Huang* et al.Synthesis and Antiproliferative Activities of Ottelione A Analogues其他ACS Medicinal Chemistry Letters1075–1080  
6102120141Huang, L. Y. L.; Lee, Y.-S.; Huang, J.-J. et al.Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1 其他Journal of Experimental and Clinical Research33  
71031201411Jiann-Jyh Huang* et al.Design and synthesis of pyrrole–5-(2,6-dichlorobenzyl)sulfonylindolin-2-ones with a C-3‘ side chains as potent Met kinase inhibitors其他RSC Advances58990–58998 Met, c-Met, indolin-2-one, kinase, oncology, hepatocyte growth factor, scatter factor 
8102220143Jiann-Jyh Huang* et al.One-flask synthesis of 1,3,5-trisubstituted 1,2,4-triazoles from nitriles and hydrazonoyl chlorides via 1,3-dipolar cycloaddition其他RSC Advances14215-14220  
9102220145Jiann-Jyh Huang* et al.Discovery of 4-Aryl-N-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 inhibitors. Part I: optimization of in vitro potencies and pharmacokinetic properties其他Journal of Medicinal Chemistry57 4098-4110  
10102220145Wang, L.-Y.; Chang, E.-C.; Yeh, M.-Y.; Chung, Y. H.; Huang, J.-J.; Wong, F. F. Synthesis of 1,3,4-oxadiazole-based aromatic and heterocyclic/phenylpyrazole derivatives 其他Heteroatom Chemistry 25 171-177  
1110312014931. Huang, L. Y. L.; Chang, C.-C.; Lee, Y.-S.; Huang, J. J.; Chuang, S.-H.; Chang, J.-M.; Kao, K.-J.Inhibition of Hec1 as a novel approach for treatment of primary liver cancer其他Cancer Chemother. Pharmacol.74 511-520  
12103120149Huang, L. Y. L.; Chang, C.-C.; Lee, Y.-S.; Chang, J.-M.; Huang, J.-J.; Chuang, S.-H.; Kao, K.-J.; LaActivity of a novel Hec1-targeted anticancer compound against breast cancer cell lines in vitro and in vivo其他Molecular Cancer Therapeutics 13 1419-1430  
13103220154黃建智Vilsmeier–Haack reagent-promoted formyloxylation of a-chloro-N-arylacetamides by formamide第一順位RSC Advances35934-35939 ilsmeier–Haack reagent, formyloxylation, formate ester, formamide, phosphorous bromide, α-formyloxy-N-arylacetamide 
14108220203Jiann-Jyh Huang et. al.The inhibition profiles of 4′-acylpyrrole–5-fluoroindolin-2-ones with a C-3′ side chain for VEGFR2, PDGFR-β, and FGFR-1 protein kinases第一順位Journal of the Chinese Chemical Society67 422-429 Pyrrole–indoline-2-one;, VEGFR2, ; PDGFR-β, ; FGFR-1, ; kinaseKinase, ; inhibition Inhibition profile 
15108220204Shih-Hsien Chuang..//...Jiann-Jyh Huang*Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy其他European Journal of Medicinal Chemistry191 112118  
16109220212Hsueh, W.-Y./.../Huang, J.-J.*Copper(I)-catalyzed nitrile-addition/N-arylation ring-closure cascade: synthesis of 5,11-dihydro-6H-indolo(3,2-c)quinolin-6-ones as potent topoisomerase-I inhibitors其他Journal of Medicinal Chemistry64 1435-1453  
17109220212Lee, C.-I./.../Huang, J.-J.*Design and synthesis of 4-anilinoquinazolines as Raf kinase inhibitors. Part 1. Selective B-Raf/B-RafV600E and potent EGFR/VEGFR2 inhibitory 4-(3-hydroxyanilino)-6-(1H-1,2,3-triazol-4-yl)quinazolines其他Bioorganic Chemistry109 104715  
18110120219Pei-Yi Tsai /.../ Jiann-Jyh Huang*Design, synthesis, and in vitro/vivo anticancer activity of 4-substituted 7-(3-fluoro-4-methoxybenzyl)-7H-pyrrolo(2,3-d)pyrimidines其他Journal of the Chinese Chemical Society68 1761-1770  

會議論文(共計13筆)
序號學年度學期年度月份作者題目通訊作者作者順位發表性質會議論文集或研討會名稱地點
10961200711Huang, J.-J. et. alDevelopment of Novel Quinolinone Derivatives as Topoisomerase I Inhibitors第一順位書面發表 Sino–French Workshop on Bioorganic and Medicinal Chemistry  
20981200910黃建智Synthesis and Structure–Activity Relationship of 3-O-Acylated (–)-Epigallocatechins as 5α-Reductase Inhibitors第一順位書面發表 Huang, J.-J.; Lee, Y.-S.; Liao, C.-B.; Chen, P.  
30981200912J.-J. Huang et. alDevelopment of Tetrahydro-1H-indol-2-ylmethyleneindolin-2-ones as Aurora Kinase Inhibitors其他壁報發表  IT’s 7th Annual Congress of International Drug Discovery Science and Technology  
4100120119J.-J. Huang et. alDiscovery of Dual B-Raf and EGFR Inhibitors第一順位口頭發表 Senior Workshop: Advanced Version of WOCJC  
51041201512Huang, J.-J.Discovery of 4-Aryl-N-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 Inhibitors. Part I: Optimization of In Vitro Potencies and Pharmacokinetic Properties第一順位書面發表 The 25th ISHC Congress  
6104220164Jiann-Jyh Huang* et al.Discovery of Novel Nek2/Hec1 Inhibitor TAI-95 Tosylate第一順位壁報發表 The 12th International Symposium on Organic Reactions  
7105120168黃建智Discovery of TAI-95 tosylate, the first-in-class anti-cancer lead candidate targeting Nek2/Hec1 interaction第一順位壁報發表 2016台灣藥學會藥物化學研討會  
81061201712Min-Sian Huang, Yu-Fen Chen, Jo Chu Lin, Ying-Shuen Lee, Shih-Hsien Chuang, Jiann-Jyh HuangSynthesis of Pyrrole–Indolin-2-ones as Multi-Kinase Inhibitors其他壁報發表 2017中國化學會年會  
91061201712Ying-Shuan E. Lee ...// ... Jiann-Jyh HuangDiscovery of 4-Aryl-N-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 Inhibitors. Part I: Optimization of In Vitro Potencies and Pharmacokinetic Properties第一順位壁報發表 2017中國化學會年會  
101061201712Ying-Shuan E. Lee, Wen Yun Hsueh, Yi-Ling Liu, Bo-Syun Huang...//... Jiann-Jyh HuangDiscovery of Hec1/Nek2 Inhibitor First-in-Class Clinical Candidate TAI-95其他壁報發表 2017中國化學會年會  
111061201712Yu-Sheng Gao...//...Jiann-Jyh Huang*Development of Novel Quinolinone Derivatives as New Anti-cancer Drugs其他壁報發表 2017中國化學會年會  
121071201811黃建智Copper(I)-Catalyzed Nitrile-Addition/N-Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro-6H-indolo〔3,2-c〕quinolin- 6-ones as Topoisomerase-I Inhibitors with Potent In Vitro and In Vivo Antitumor Activities第一順位壁報發表 The 13th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-13) and the 4th  
13108120199Jiann-Jyh HuangA New Cascade Reaction for the Synthesis of 5,11-Dihydro-6H-indolo〔3,2-c〕quinolin-6-ones as Topoisomerase-I Inhibitors 第一順位壁報發表 27th International Society of Heterocyclic Chemistry Congress  

專書著作(共計1筆)
序號學年度學期年度月份作者書名出版社國際標準書號
1095220072黃建智2007醫藥產業年鑑978-957-8514-76-8  

研究計畫(共計13筆)
備註欄說明:「教師研究計畫管理系統轉入之計畫」(係指依「國立嘉義大學產學合作計畫實施要點」第3點規定,與政府機關、法人、公民營事業機構、民間團體、學術研究機構等合作辦理有關事項,以本校名義與合作機構辦理簽約,其經費撥入本校之產學合作計畫。)
序號學年度學期年度月份參與性質委辦單位計畫名稱開始日期結束日期經費備註欄
11021201308國家科學及技術委員會具雙雜環主結構之化合物合成與其抗癌活性評估(1/2)2013/08/012014/07/311800000
21021201308國家科學及技術委員會具雙雜環主結構之化合物合成與其抗癌活性評估2013/08/012015/07/313600000
31031201408國家科學及技術委員會具雙雜環主結構之化合物合成與其抗癌活性評估(2/2)2014/08/012015/07/311800000
41041201508國家科學及技術委員會2,6-雙甲基-1-鹵苯與胺基唑之銅催化C–N耦合反應開發(1/2)2015/08/012016/07/311888000
51042201605其他民間企業團體-其他民間企業團體或個人Sirolimus衍生化合物製備2016/05/162016/08/15180000
61051201608國家科學及技術委員會2,6-雙甲基-1-鹵苯與胺基唑之銅催化C–N耦合反應開發(2/2)2016/08/012017/07/312020000
71052201705其他民間企業團體-其他民間企業團體或個人乳酸微胞包覆化療藥物代工與測試2017/05/012018/12/312240000
81061201708國家科學及技術委員會應用於indolo[2,3-c]quinolinones與其類似四環雜環合成之金屬催化串聯反應開發2017/08/012018/07/311500000
91071201812其他政府機關-其他政府單位類緣物標準品合成2018/12/012021/11/3098000
101081201909其他政府機關-其他政府單位類緣物標準品合成(III)2019/09/182019/11/29395000教師研究計畫管理系統轉入之計畫
111081201909其他政府機關-其他政府單位類緣物標準品合成(II)2019/09/202020/02/2985000
121101202108計畫主持人國家科學及技術委員會Benzofuro[3,2-c]quinolinones之新穎金屬催化串聯反應合成法開發與其作為G-四聯體穩定劑及第二型拓樸異構?α亞型選擇性抑制劑之研究2021/08/012022/07/31900000教師研究計畫管理系統轉入之計畫
131111202208計畫主持人國家科學及技術委員會金屬催化串聯反應於合成全新與少見四環雜環之研究(1/2)2022/08/012023/07/311400000教師研究計畫管理系統轉入之計畫

專利(共計6筆)
序號學年度學期年度月份專利分類申請國專利種類專利名稱字號開始日期結束日期金額
10931200411國際美國發明Organometallic ComplexUS 6,812,2472002/09/012022/08/310
2099220113國際美國發明Indolinone Compounds as Kinase InhibitorsUS7,897,6022009/06/262029/06/25
3102220147國際美國發明Quinazoline Compounds as Kinase InhibitorsUS 8,785,7592011/12/012031/11/300
41041201510國際美國發明GLP-1 Potentiators from Hedychium coronarium and Their Applications 2013/06/012033/05/310
5103220152國際多國發明Modulators of HEC1 Activity And Methods ThereforUS 8,946,2682010/03/012030/02/280
6103220154國際多國發明Modulators of Hec1 Activity And Methods ThereforUS 8,999,9832012/11/012032/10/310

學術活動(共計56筆)
序號學年度學期年度月份活動分類活動名稱活動地點/期刊學報/比賽名稱
11041201508學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
21041201508學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
31041201508學術期刊論文審查Anti-Cancer Agents in Medicinal Chemistry期刊審查Anti-Cancer Agents in Medicinal Chemistry 
41041201509學術期刊論文審查Molbank期刊審查Molbank 
51041201509學術期刊論文審查Synthetic Communications期刊審查 Synthetic Communications 
61041201511主編、副主編Synthetic Communications期刊審查Synthetic Communications 
71042201602學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
81042201602學術期刊論文審查Molecules期刊審查Molecules 
91042201603學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
101042201604學術期刊論文審查Journal of Medicinal Chemistry期刊審查Journal of Medicinal Chemistry 
111042201605學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
121042201607學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
131051201608學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
141051201610學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
151051201610學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications  
161051201611學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
171051201611學術期刊論文審查Heteroatom Chemistry期刊審查Heteroatom Chemistry 
181051201612學術期刊論文審查Environmental Chemistry Letters期刊審查Environmental Chemistry Letters 
191051201701學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
201051201701學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
211052201702學術期刊論文審查Journal of the Chinese Chemical Society期刊審查Journal of the Chinese Chemical Society 
221052201702學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
231052201703學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
241052201704學術期刊論文審查Chemical Communications期刊審查Chemical Communications 
251052201704學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
261052201705學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
271061201708學術期刊論文審查Scientific Reports期刊審查Scientific Reports 
281061201708學術期刊論文審查Molecules期刊審查Molecules 
291061201708學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
301061201709學術期刊論文審查Molecules期刊審查Molecules 
311061201711學術期刊論文審查Molbank期刊審查Molbank 
321061201801學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
331062201802學術期刊論文審查Molecules期刊審查Molecules 
341062201804學術期刊論文審查Journal of the Chinese Chemical Society期刊審查Journal of the Chinese Chemical Societ 
351062201804學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
361062201804學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
371062201805學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
381062201805學術期刊論文審查Molecules期刊審查Molecules 
391062201806學術期刊論文審查Molecules期刊審查Molecules 
401062201807學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
411062201807學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
421062201807學術期刊論文審查Journal of the Chinese Chemical Society期刊審查Journal of the Chinese Chemical Society 
431071201808學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
441071201901學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
451072201906學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
461072201907學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
471081201908學術期刊論文審查Journal of Medicinal Chemistry期刊審查Journal of Medicinal Chemistry 
481081201909學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
491081201910學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
501081201911學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
511081201912學術期刊論文審查Current Topics in Medicinal Chemistry期刊審查Current Topics in Medicinal Chemistry 
521081202001學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
531082202002學術期刊論文審查Current Topics in Medicinal Chemistry期刊審查Current Topics in Medicinal Chemistry 
541082202003學術期刊論文審查Molecules期刊審查Molecules 
551082202003學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications 
561082202003學術期刊論文審查Synthetic Communications期刊審查Synthetic Communications