研究成果列表
單位名稱生化科技學系教師姓名張心怡
教師分級教授專兼任專任
在校狀態在職行政職務生化科技學系主任暨所長

期刊論文(共計39筆)
序號學年度學期年度月份作者題目通訊作者作者順位期刊名稱卷數頁數關鍵字
1092120041Matthew R. Williamson, Hsin-I Chang and Allan G. A. CoombesGravity spun polycaprolactone fibres: controlling release of a hydrophilic macromolecule (ovalbumin) and a lipophilic drug (progesterone)第二順位 Biomaterials   
2093120051Hsin-I Chang, Matthew R. Williamson, Perrie Y, and Allan G. A. CoombesPrecipation casting of drug-loaded microporous matrices: Incorporation of progesterone by co-dissolution第一順位Journal of Controlled Release   
3094120061Hsin-I Chang, Perrie Y., A.G. A. Coombes, Delivery of the antibiotic gentamicin sulphate from precipitation cast matrices of polycaprolactone第一順位 Journal of Controlled Release   
4095120071Y. Wang, H-I Chang, D.F. Wertheim, A.S Jones, A.G.A. Coombes, Polycaprolactone-based biocomposite scaffolds for tissue engineering. Assessment of macroporosity using micro-computed tomography (MicroCT). 第二順位Tissue engineering   
5096120081Hsin-I Chang, Y-C Lau, C. Yen, A.G. A. Coombes. Controlled release of an antibiotic, gentamicin sulphate, from gravity spun polycaprolactone fibres, 第一順位Journal of Biomedical Materials Research: Part A   
6096120081Yiwei Wang , Hsin-I Chang, D. Wertheim, Allan Jones, Chris Jackson, Allan G.A. CoombesCharacterisation of the macroporosity of polycaprolactone-based biocomposites and release kinetics for drug delivery其他 Biomaterials   
7097120091Yeh CC, Li YT, Chiang P H, Huang C H, Wang Y W, Chang H ICharacterizing Microporous PCL Matrices for Application of Tissue Engineering第一順位 Journal of Medical and Biological Engineering   
8097120091Yeh CC, Chang HI, Chiang JK, Tsai WT, Chen LM, Wu CP, Chien S, Chen CNRegulation of Plasminogen Activator Inhibitor-1 Expression in Osteoarthritic Chondrocytes by Fluid Shear Stress: Role of PKC第一順位 Arthritis Rheum.    
9097120091Yiwei Wang, Hsin-I. Chang, Xiongwei Li, Oyar Alpar, Allan G.A. CoombesDelivery of bioactive macromolecules from microporous polymer matrices: release kinetics and activity profiles of lysozyme, collagenase and catalase. 第二順位European Journal of Pharmaceutical Sciences   
10097120091Sung ML, Wu CC, Chang HI, Yen CK, Chen HR, Cheng JC, Chien S, Chen CN.Shear Stress Inhibits Homocysteine-Induced Stromal Cell Derived Factor-1 Expression in Endothelial Cells.第三順位Circ Res.    
11097120091Sherry Y. Wu, Lisa N. Putral, Mingtao Liang, Hsin-I. Chang, Nigel M. Davies and Nigel A. J. McMillanDevelopment of a Novel Method for Formulating Stable siRNA-Loaded Lipid Particles for In vivo Use其他Pharmaceutical Research   
12097120091Christelle Capini, Montree Jaturanpinyo, Hsin-I Chang, Srinivas Mutalik, Alice McNally, Shayna Street, Raymond Steptoe, Brendan O'Sullivan, Nigel Davies, Ranjeny ThomasAntigen-specific suppression of inflammatory arthritis using liposomes第三順位Journal of immunology   
13098120101Mou-Tsy Chou, Sheng-Nan Chang, Mao-Ling Sung, Hsin-I Chang, Hsing-Chun Kuo, Chieh Ke, Cheng-Nan Chen, Fibrillar Collagen Inhibits Proliferation and Induces Differentiation of Placental-Derived Multipotent Cells into Smooth Muscle Cells. 其他Biomaterial   
14098120101Hsin-I chang, Y. Wang, Perrie Y., A.G. A. Coombe. Microporous polycaprolactone matrices for drug delivery and tissue engineering: the release behavior of bioactive having extremes of aqueous solubility.第一順位J. DRUG DEL. SCI. TECH.   
15098120101Hsin-I Chang, Ming-Syun Yang, Mong Liang, The Synthesis, Characterization and Antibacterial Activity of Quaternized Poly(2,6-dimethyl-1,4-phenylene oxide)s Modified With Ammonium and Phosphonium Salts. 第一順位Reactive and Functional Polymers.   
161001201111張心怡Vaginal delivery of siRNA using a novel PEGylated lipoplex-entrapped alginate scaffold system. 第二順位Journal of controlled release155 418-426  
17099220116Susan Hua , Hsin-I Chang , Nigel M. Davies , Peter J. Cabot, Susan Hua , Targeting of ICAM-1–directed immunoliposomes specifically to activated endothelial cells with low cellular uptake: use of an optimized procedure for the coupling of low concentrations of antibody to liposomes. 第二順位Journal of Liposome Research21 95-105  
18100220125張心怡Evaluation of the Correlation between Focal Adhesion Kinase Phosphorylation and Cell Adhesion Force Using “DEP” Technology. 其他Sensors 12 59451-5965  
191021201310Cheng-Chang Lien; Meng-Chien Wu; Ming-kung Yeh; Hsin-I. Chang. Using atomic force microscope to investigate the influence of UVB radiation on cell behaviour and elasticity of dermal fibroblasts其他Int. J. of Nanotechnology10 973-983  
20101220134Yeh CC, Chang SF, Huang TY, Chang HI, Kuo HC, Wu YC, Hsieh CH, Shi CS, Chen CN.Shear stress modulates macrophage-induced urokinase plasminogen activator expression in human chondrocytes. 其他 Arthritis Res Ther.15 R53  
21103220154Chih-Chang Yeh, Yu-Han Su, Yu-Jhe Lin, Pin-Jyun Chen, Chung-Sheng Shi, Cheng-Nan Chen, Hsin-I ChangEvaluation of the protective effects of curcuminoid-loaded liposomes (Cur-Lip and BDMC-Lip) against bone turnover in a cell-based model of osteoarthritis.其他 Drug Design, Development and Therapy 2285-2230  
22104220167Chien-Liang Fang, Ling-Hung Huang , Hung-Yueh Tsai and Hsin-I ChangDermal Lipogenesis Inhibits Adiponectin Production in Human Dermal Fibroblasts while Exogenous Adiponectin Administration Prevents against UVA-Induced Dermal Matrix Degradation in Human Skin其他International Journal of Molecular Sciences1129  
231061201710Chang SF, Huang KC, Cheng CC, Su YP, Lee KC, Chen CN, Chang HI. Glucose adsorption to chitosan membranes increases proliferation of human chondrocyte via mammalian target of rapamycin complex 1 and sterol regulatory element-binding protein-1 signaling.其他J Cell Physiol. 232 2741-2749.  
241052201745. Wang, Y. M.; Zheng, S. X.; Chang, H. I.; H.Y. Tsai, H. Y.; Liang, Microwave-Assisted Synthesis of Thermo- and pH-responsive Antitumor Drug Carrier Through Reversible Addition-Fragmentation Chain Transfer Polymerization.第三順位Express Polym. Lett. 11 293-307  
25105220176Su YP, Chen CN, Chang HI, Huang KC, Cheng CC, Chiu FY, Lee KC, Lo CM, Chang SF.Low Shear Stress Attenuates COX-2 Expression Induced by Resistin in Human Osteoarthritic Chondrocytes.其他 J Cell Physiol.232 1448-1457.  
26106120181Chang SF, Yeh CC, Chen PJ, Chang HI.The Impact of Lipid Types and Liposomal Formulations on Osteoblast Adiposity and Mineralization其他Molecules23 95  
271061201811. Dai NT, Chang HI, Wang YW, Fu KY, Huang TC, Huang NC, Li JK, Hsieh PS, Dai LG, Hsu CK, Maitz PK.Restoration of skin pigmentation after deep partial or full-thickness burn injury.第一順位Adv Drug Deliv Rev. 123 155-164  
28106220183Fang CL, Wang Y, Tsai KH, Chang HI. Liposome-Encapsulated Baicalein Suppressed Lipogenesis and Extracellular Matrix Formation in Hs68 Human Dermal Fibroblasts.其他Front Pharmacol.155  
29106220184Su YP, Chen CN, Huang KC, Chang HI, Lee KC, Lo CM, Chang SF. Leptin induces MMP1/13 and ADAMTS 4 expressions through bone morphogenetic protein-2 autocrine effect in human chondrocytes. 其他J Cell Biochem.119 3716-3724  
30107220192Wei LG, Chang HI, Wang Y, Hsu SH, Dai LG, Fu KY, Dai NT. A gelatin/collagen/polycaprolactone scaffold for skin regeneration.第一順位 PeerJ.e6358   
31109120208Widyowati R, Suciati S, Haryadi DM, Chang HI, Suryawan IN, Utama AW.The Effect of Rusa unicolor Antler Deer Extracts from East Kalimantan in Bone Turnover Cell Models其他Turkish Journal of Pharmaceutical Sciences17 440-445  
32109220212Widyowati R, Suciati S, Haryadi DM, Chang HI, Suryawan IN, Tarigan N.The effect of deer antler from East Kalimantan to increase trabecular bone density and calcium levels in serum on osteoporotic mice其他J Basic Clin Physiol Pharmacol.2021 33580921.  
33109220216Widyowati R, Purwitasari N, Oktarina RD, Ekasari W, Khairunnisa S, Chang HI. Exploration of several plants from Baung Forest on bone formation cell models其他 Journal of Basic and Clinical Physiology and Pharmacology32 831-837  
34110120218Priyanka Pandya, Prabhanjan Giram, Ritesh P. Bhole, Hsin-I Chang, Sushil Y. Raut,Nanocarriers based oral lymphatic drug targeting: Strategic bioavailability enhancement approaches其他Journal of Drug Delivery Science and Technology64 102585  
351111202210Lee Kochao, Wu Kuen-Lin, Chang Shun-Fu, Chang Hsin-I, Chen Cheng-Nan, Chen Yih-Yuan.Fermented Ginger Extract in Natural Deep Eutectic Solvent Enhances Cytotoxicity by Inhibiting NF-κB Mediated CXC Chemokine Receptor 4 Expression in Oxaliplatin-Resistant Human Colorectal Cancer Cells.其他Antioxidants11 2057  
36110220224Chang, H.-I.; Shao, C.-W.; Huang, E.; Huang, K.-Y.Development of Astaxanthin-Loaded Nanosized Liposomal Formulation to Improve Bone Health. 第一順位Pharmaceuticals. 15 490  
37110220227Chang, H.-I.; Chen, C.-N.; Huang, K.-Y.Mechanical Stretch-Induced NLRP3 Inflammasome Expression on Human Annulus Fibrosus Cells Modulated by Endoplasmic Reticulum Stress.第一順位Int. J. Mol. Sci. 23 7951  
38111120228Chen CN, Chang HI, Yen CK, Liu WL, Huang KY.Mechanical Stretch Induced Osteogenesis on Human Annulus Fibrosus Cells through Upregulation of BMP-2/6 Heterodimer and Activation of P38 and SMAD1/5/8 Signaling Pathways.第一順位Cells.11 2600  
39111220234Raut SY, Fu K, Taichun H, Gahane A, Chaudhari D, Kushwah V, Suresh Managuli R, Hegde AR, Jain S, KalEngineered Nano-carrier systems for the oral targeted delivery of follicle stimulating Hormone: Development, characterization, and, assessment of in vitro and in vivo performance and targetability. 2023 Apr 25;637:122868.其他 Int J Pharm.637 122868.  

會議論文(共計3筆)
序號學年度學期年度月份作者題目通訊作者作者順位發表性質會議論文集或研討會名稱地點
11101202112張心怡Analysis of the active components and bioactivities from natural products第一順位口頭發表 AICTE ATAL FDP Programme Pimpri, Pune,India, 
2110220225張心怡The Pathology of Osteoarthritis and Current Research Works第一順位口頭發表 UNAIR conference Sarabaya, Indonesia 
3112120238張心怡Mechanical Stretch-Induced NLRP3 Inflammasome Expression on Human Annulus Fibrosus Cells Modulated by Endoplasmic Reticulum Stress..第一順位口頭發表 Second Trilateral Symposium on SDGs Takamatsu city, Kagawa, Japan 

研究計畫(共計23筆)
備註欄說明:「教師研究計畫管理系統轉入之計畫」(係指依「國立嘉義大學產學合作計畫實施要點」第3點規定,與政府機關、法人、公民營事業機構、民間團體、學術研究機構等合作辦理有關事項,以本校名義與合作機構辦理簽約,其經費撥入本校之產學合作計畫。)
序號學年度學期年度月份參與性質委辦單位計畫名稱開始日期結束日期經費備註欄
10971200808計畫主持人國家科學及技術委員會研發新“生物組織結合血管移植物”來作為藥物載體或組織工程支架2008/08/012009/07/31970000
20981200908計畫主持人國家科學及技術委員會探討不同藥物及載體對正常、受損及未受損造骨細胞之影響2009/08/012011/07/314000000
30981200908計畫主持人國家科學及技術委員會探討不同藥物及載體對正常、受損及未受損造骨細胞之影響(1/3)2009/08/012012/07/311600000
40981200908計畫主持人國家科學及技術委員會探討不同藥物及載體對正常、受損及未受損造骨細胞之影響2009/08/012012/07/314000000
50991201008計畫主持人國家科學及技術委員會探討不同藥物及載體對正常、受損及未受損造骨細胞之影響(2/3)2010/08/012012/07/311300000
60992201105計畫主持人其他民間企業團體-其他基金(如基金會)荔枝廢棄物應用於機能性化妝保養品之開發計畫2011/05/012011/12/31150000
71001201108計畫主持人國家科學及技術委員會探討不同藥物及載體對正常、受損及未受損造骨細胞之影響(3/3)2011/08/012012/07/311100000
81021201308計畫主持人國家科學及技術委員會奈米遞送系統應用於退化性關節炎的治療2013/08/012014/07/31900000
91021201310計畫主持人其他民間企業團體-其他民間企業團體或個人八方燕燕窩應用於皮膚保養品之細胞活性評估2013/10/152014/10/14250000
101032201507計畫主持人國家科學及技術委員會大專生研究計畫:以幾丁聚醣和縮水甘油基三甲基氯化銨途徑合成之N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) 對骨細胞新陳代謝之影響2015/07/012016/02/2948000
11104220162共同主持人農業部農業試驗所嘉義農業試驗分所機能性水稻優質安全生產技術建立及加值產品研發2016/02/282016/11/301440000
121042201607計畫主持人國家科學及技術委員會大專生計畫-改良幾丁聚醣衍生物N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride(HTCC)之合成方法及觀察對RAW264.7分化之蝕骨細胞的影響(吳依倫)2016/07/012017/02/2848000
131052201707計畫主持人國家科學及技術委員會大專生計畫-蓼科植物萃取物抑菌活性及其應用潛力之研究(郭瑋倫)2017/07/012018/02/2848000
141061201709計畫主持人其他民間企業團體-其他民間企業團體或個人臺鹽樣品應用於軟骨保養之細胞活性評估2017/09/012018/08/31340000
151061201709計畫主持人其他民間企業團體-其他民間企業團體或個人使用常溫高壓均質法製備包覆菱角殼萃取物的固體脂質奈米粒子並測試其美白與抗皮膚老化之功效性2017/09/012018/08/31400000
161062201804計畫主持人農業部農業試驗所嘉義農業試驗分所咖啡葉調節代謝症候群保健飲品原料之機能性分析與生物活性測試2018/04/182018/11/30372000
171071201901計畫主持人教育部108年度大專校院健康促進學校實施計畫2019/01/012019/12/31200000
181081201908計畫主持人國家科學及技術委員會化學修飾幾丁聚醣並評估幾丁聚醣水溶性衍生物對退化性關節炎滑液膜纖維母細胞之影響2019/08/012020/07/31650000
191091202101計畫主持人農業部農業試驗所嘉義農業試驗分所咖啡資源物之機能性分析與生物活性測試2021/01/052021/11/30190000教師研究計畫管理系統轉入之計畫
201092202105計畫主持人其他民間企業團體-其他民間企業團體或個人銘舷草本抗菌液測試其細胞毒性與抗菌之功效性2021/05/052022/05/04150000教師研究計畫管理系統轉入之計畫
211092202107計畫主持人國家科學及技術委員會大專學生研究計畫大專生計畫:HTCC作為傷口敷料的潛力(指導學生:張立婕)2021/07/012022/02/2848000教師研究計畫管理系統轉入之計畫
221102202207共同主持人國家科學及技術委員會科研創業計畫:超音波高效植物活性成分萃取技術2022/07/012023/06/307100000
231122202402共同主持人國家科學及技術委員會建立台灣機能性作物綠色萃取產業鏈平台(1/3)2024/02/012025/01/312652000

學術活動(共計4筆)
序號學年度學期年度月份活動分類活動名稱活動地點/期刊學報/比賽名稱
11082202006學術期刊論文審查antioxidants-823963antioxidants 
21092202103學術期刊論文審查genes-1178909 reviewerGenes 
31101202108學術期刊論文審查Experimental Cell Research-21-1275 審稿員Experimental Cell Research 
41102202204學術期刊論文審查biomimetrics-1698963 審稿員biomimetrics 

推廣工作(共計1筆)
序號學年度學期年度月份推廣類別推廣名稱推廣地點
11121202312其他碩士班學生楊惠雯的碩士學位考試之口試委員 

其它(共計1筆)
序號學年度學期年度月份人員名稱題目(標題)其它
11031201411張心怡嘉義大學103年度獲選績優兼任行政工作教師嘉義大學103年度獲選績優兼任行政工作教師及職員