研究成果列表
單位名稱生化科技學系教師姓名張心怡
教師分級教授專兼任專任
在校狀態在職行政職務生化科技學系主任暨所長

期刊論文(共計35筆)
序號學年度學期年度月份作者題目通訊作者作者順位期刊名稱卷數頁數關鍵字
1092120041Matthew R. Williamson, Hsin-I Chang and Allan G. A. CoombesGravity spun polycaprolactone fibres: controlling release of a hydrophilic macromolecule (ovalbumin) and a lipophilic drug (progesterone)第二順位 Biomaterials   
2093120051Hsin-I Chang, Matthew R. Williamson, Perrie Y, and Allan G. A. CoombesPrecipation casting of drug-loaded microporous matrices: Incorporation of progesterone by co-dissolution第一順位Journal of Controlled Release   
3094120061Hsin-I Chang, Perrie Y., A.G. A. Coombes, Delivery of the antibiotic gentamicin sulphate from precipitation cast matrices of polycaprolactone第一順位 Journal of Controlled Release   
4095120071Y. Wang, H-I Chang, D.F. Wertheim, A.S Jones, A.G.A. Coombes, Polycaprolactone-based biocomposite scaffolds for tissue engineering. Assessment of macroporosity using micro-computed tomography (MicroCT). 第二順位Tissue engineering   
5096120081Hsin-I Chang, Y-C Lau, C. Yen, A.G. A. Coombes. Controlled release of an antibiotic, gentamicin sulphate, from gravity spun polycaprolactone fibres, 第一順位Journal of Biomedical Materials Research: Part A   
6096120081Yiwei Wang , Hsin-I Chang, D. Wertheim, Allan Jones, Chris Jackson, Allan G.A. CoombesCharacterisation of the macroporosity of polycaprolactone-based biocomposites and release kinetics for drug delivery其他 Biomaterials   
7097120091Yeh CC, Li YT, Chiang P H, Huang C H, Wang Y W, Chang H ICharacterizing Microporous PCL Matrices for Application of Tissue Engineering第一順位 Journal of Medical and Biological Engineering   
8097120091Yeh CC, Chang HI, Chiang JK, Tsai WT, Chen LM, Wu CP, Chien S, Chen CNRegulation of Plasminogen Activator Inhibitor-1 Expression in Osteoarthritic Chondrocytes by Fluid Shear Stress: Role of PKC第一順位 Arthritis Rheum.    
9097120091Yiwei Wang, Hsin-I. Chang, Xiongwei Li, Oyar Alpar, Allan G.A. CoombesDelivery of bioactive macromolecules from microporous polymer matrices: release kinetics and activity profiles of lysozyme, collagenase and catalase. 第二順位European Journal of Pharmaceutical Sciences   
10097120091Sherry Y. Wu, Lisa N. Putral, Mingtao Liang, Hsin-I. Chang, Nigel M. Davies and Nigel A. J. McMillanDevelopment of a Novel Method for Formulating Stable siRNA-Loaded Lipid Particles for In vivo Use其他Pharmaceutical Research   
11097120091Christelle Capini, Montree Jaturanpinyo, Hsin-I Chang, Srinivas Mutalik, Alice McNally, Shayna Street, Raymond Steptoe, Brendan O'Sullivan, Nigel Davies, Ranjeny ThomasAntigen-specific suppression of inflammatory arthritis using liposomes第三順位Journal of immunology   
12097120091Sung ML, Wu CC, Chang HI, Yen CK, Chen HR, Cheng JC, Chien S, Chen CN.Shear Stress Inhibits Homocysteine-Induced Stromal Cell Derived Factor-1 Expression in Endothelial Cells.第三順位Circ Res.    
13098120101Mou-Tsy Chou, Sheng-Nan Chang, Mao-Ling Sung, Hsin-I Chang, Hsing-Chun Kuo, Chieh Ke, Cheng-Nan Chen, Fibrillar Collagen Inhibits Proliferation and Induces Differentiation of Placental-Derived Multipotent Cells into Smooth Muscle Cells. 其他Biomaterial   
14098120101Hsin-I chang, Y. Wang, Perrie Y., A.G. A. Coombe. Microporous polycaprolactone matrices for drug delivery and tissue engineering: the release behavior of bioactive having extremes of aqueous solubility.第一順位J. DRUG DEL. SCI. TECH.   
15098120101Hsin-I Chang, Ming-Syun Yang, Mong Liang, The Synthesis, Characterization and Antibacterial Activity of Quaternized Poly(2,6-dimethyl-1,4-phenylene oxide)s Modified With Ammonium and Phosphonium Salts. 第一順位Reactive and Functional Polymers.   
16098120101Wang Y, Wertheim DF, Jones AS, Chang HI, Coombes AG. Micro-CT analysis of matrix-type drug delivery devices and correlation with protein release behaviour. 第三順位J Pharm Sci.   
171001201110張心怡The effect of polymer molecular weight and UV radiation on physical properties and bioactivities of PCL films.其他Cellular Polymers30 227-242  
181001201111張心怡Vaginal delivery of siRNA using a novel PEGylated lipoplex-entrapped alginate scaffold system. 第二順位Journal of controlled release155 418-426  
191001201112張心怡Clinical development of liposome-based drugs: Formulation, characterization and therapeutic efficacy.第一順位International Journal of Nanomedicine49-60  
20099220114張心怡Homocysteine induces smooth muscle cell proliferation through differential regulation of cyclins A and D1 expression. 其他J Cell Physiol.226 1017-1026  
21099220114張心怡Study on the effect of detection of preservative doses in raw milk samples. 其他Journal of the Agricultural Association of Taiwan12 287-302  
22099220116Susan Hua , Hsin-I Chang , Nigel M. Davies , Peter J. Cabot, Susan Hua , Targeting of ICAM-1–directed immunoliposomes specifically to activated endothelial cells with low cellular uptake: use of an optimized procedure for the coupling of low concentrations of antibody to liposomes. 第二順位Journal of Liposome Research21 95-105  
23100220125張心怡Evaluation of the Correlation between Focal Adhesion Kinase Phosphorylation and Cell Adhesion Force Using “DEP” Technology. 其他Sensors 12 59451-5965  
241021201310Cheng-Chang Lien; Meng-Chien Wu; Ming-kung Yeh; Hsin-I. Chang. Using atomic force microscope to investigate the influence of UVB radiation on cell behaviour and elasticity of dermal fibroblasts其他Int. J. of Nanotechnology10 973-983  
25101220134Yeh CC, Chang SF, Huang TY, Chang HI, Kuo HC, Wu YC, Hsieh CH, Shi CS, Chen CN.Shear stress modulates macrophage-induced urokinase plasminogen activator expression in human chondrocytes. 其他 Arthritis Res Ther.15 R53  
26103220154Chih-Chang Yeh, Yu-Han Su, Yu-Jhe Lin, Pin-Jyun Chen, Chung-Sheng Shi, Cheng-Nan Chen, Hsin-I ChangEvaluation of the protective effects of curcuminoid-loaded liposomes (Cur-Lip and BDMC-Lip) against bone turnover in a cell-based model of osteoarthritis.其他 Drug Design, Development and Therapy 2285-2230  
27104220167Chien-Liang Fang, Ling-Hung Huang , Hung-Yueh Tsai and Hsin-I ChangDermal Lipogenesis Inhibits Adiponectin Production in Human Dermal Fibroblasts while Exogenous Adiponectin Administration Prevents against UVA-Induced Dermal Matrix Degradation in Human Skin其他International Journal of Molecular Sciences1129  
281061201710Chang SF, Huang KC, Cheng CC, Su YP, Lee KC, Chen CN, Chang HI. Glucose adsorption to chitosan membranes increases proliferation of human chondrocyte via mammalian target of rapamycin complex 1 and sterol regulatory element-binding protein-1 signaling.其他J Cell Physiol. 232 2741-2749.  
291052201745. Wang, Y. M.; Zheng, S. X.; Chang, H. I.; H.Y. Tsai, H. Y.; Liang, Microwave-Assisted Synthesis of Thermo- and pH-responsive Antitumor Drug Carrier Through Reversible Addition-Fragmentation Chain Transfer Polymerization.第三順位Express Polym. Lett. 11 293-307  
30105220176Su YP, Chen CN, Chang HI, Huang KC, Cheng CC, Chiu FY, Lee KC, Lo CM, Chang SF.Low Shear Stress Attenuates COX-2 Expression Induced by Resistin in Human Osteoarthritic Chondrocytes.其他 J Cell Physiol.232 1448-1457.  
31106120181Chang SF, Yeh CC, Chen PJ, Chang HI.The Impact of Lipid Types and Liposomal Formulations on Osteoblast Adiposity and Mineralization其他Molecules23 95  
321061201811. Dai NT, Chang HI, Wang YW, Fu KY, Huang TC, Huang NC, Li JK, Hsieh PS, Dai LG, Hsu CK, Maitz PK.Restoration of skin pigmentation after deep partial or full-thickness burn injury.第一順位Adv Drug Deliv Rev. 123 155-164  
33106220183Fang CL, Wang Y, Tsai KH, Chang HI. Liposome-Encapsulated Baicalein Suppressed Lipogenesis and Extracellular Matrix Formation in Hs68 Human Dermal Fibroblasts.其他Front Pharmacol.155  
34106220184Su YP, Chen CN, Huang KC, Chang HI, Lee KC, Lo CM, Chang SF. Leptin induces MMP1/13 and ADAMTS 4 expressions through bone morphogenetic protein-2 autocrine effect in human chondrocytes. 其他J Cell Biochem.119 3716-3724  
35107220192Wei LG, Chang HI, Wang Y, Hsu SH, Dai LG, Fu KY, Dai NT. A gelatin/collagen/polycaprolactone scaffold for skin regeneration.第一順位 PeerJ.e6358   

會議論文(共計14筆)
序號學年度學期年度月份作者題目通訊作者作者順位發表性質會議論文集或研討會名稱地點
1094220064Chang H-I., Lau Y-C., Yen C., Coombes AGA. Antibiotic-loaded, high compliance PCL fibres for applications in soft tissue engineering.  2006 material Congress London, UK 
2095220077 Hsin-I Chang, Yinghe He ,Nigel DaviesMicroparticles formulation by a single step in-line emulsification.   34 Annual Meeting and Exposition of the controlled release society Long Beach California USA 
30971200811Chih-Chang Yhe, Yun-Ting Li, Pei Hsiu Chiang, Yiwei Wang, Hsin-I ChangThe characterizing PCL microporous matrices for the application in bone tissue engineering.  Tissue engineering & regenerative medicine international society- Asia Pacific Chapter Meeting, Taipei Taiwan 
40971200811Hsin-I Chang, Chao-Wei Chang, Mong Liang, The MAOS polymer formation with narrow distribution for chemotherapy application.  Tissue engineering & regenerative medicine international society- Asia Pacific Chapter Meeting Taipei Taiwan 
50981200912Hsin-I Chang, Yiwei Wang, Allan G. A. Coombes., Microporous Polycaprolactone Matrices in Drug Delivery. 11 Pacific Polymer Conference Cairns Australia 
6097220097Chih-Chang Yhe, Yun-Ting Li, Pei Hsiu Chiang, Yiwei Wang, Hsin-I Chang, The characterizing PCL microporous matrices for the application in bone tissue engineering.  36 Annual Meeting and Exposition of the controlled release society Copenhagen Denmark 
70991201010Chih-C. YEH, Cheng-N. CHEN, Yun-T. LI, Hsin-K. WANG, Chih-C. LIN, Hsin-I CHANGThe influence of dexamethasone on the growth and differentiation of bone cells 12th Asian Pacific Congress of clinical Biochemistry seoul, Korean 
8099220114Cheng-Chang Lien,Meng-Chien Wu, Hsin-I Chang, The influence of UVB radiation on proliferation and Young’s modulus of dermal fibroblasts. 第一順位壁報發表  The 2nd International Conference on Biomedical Engineering and Computer Science Wuhan, China 
9100220127張心怡The effect of exopolysaccharides extrated from Botryosphaeria rhodina on bone formation. 其他口頭發表 39 Annual Meeting and Exposition of the controlled release society Quebec city Canada 
10101220136張心怡The Application of Curcumin-Loaded Liposomes on Osteoporosis Treatment. 其他壁報發表  Osteoporosis Treatment. 2nd Joint Meeting of the International Bone and Mineral Society and The Jap Kobe, Japan 
111031201411張心怡The application of curcumin-loaded liposomes on osteoarthritics treatment.其他口頭發表  The 1st international conference on pharmaceutics and pharmaceutical sciences  Pullman Surabaya City, Indonesia 
12102220145張心怡Local activities of the membranes associated with glycosaminoglycan-chitosan complexes in bone cells. 其他壁報發表 CBPS 2014: International Conference on Biomedicine and Pharmaceutical Sciences Tokyo, Japan 
131051201611Chien-Liang Fang, Hung-Yueh Tsai, Hsin-Ni Lin, Hsin-I Chang. Baicalein-loaded liposomes may inhibit ADM-induced steatosis in a cell model of human dermal fibroblasts. 第三順位壁報發表 The 6th international symposium in phyt 嘉義,台灣 
14104220165Chih-Chang Yeh, Chia-Wen Chang, Hsin-I Chang. Investigate biological and mechanical alteration of 7F2 mouse osteoblasts between osteogenic and adipogenic differentiation.第三順位壁報發表 The 8th International Symposium on Machinery and Mechatronics for Agricultural and Biosystems Engine Niigata, Japan 

專書著作(共計2筆)
序號學年度學期年度月份作者書名出版社國際標準書號
1100120118 Hsin-I Chang and Yiwei Wang,Regenerative Medicine and tissue engineering-cells and biomaterials 
2102120139張心怡生物機電工程概論滄海圖書978-986-5937-66-9 

研究計畫(共計18筆)
備註欄說明:「教師研究計畫管理系統轉入之計畫」(係指依「國立嘉義大學產學合作計畫實施要點」第3點規定,與政府機關、法人、公民營事業機構、民間團體、學術研究機構等合作辦理有關事項,以本校名義與合作機構辦理簽約,其經費撥入本校之產學合作計畫。)
序號學年度學期年度月份參與性質委辦單位計畫名稱開始日期結束日期經費備註欄
10971200808計畫主持人科技部研發新“生物組織結合血管移植物”來作為藥物載體或組織工程支架2008/08/012009/07/31970000
20981200908計畫主持人科技部探討不同藥物及載體對正常、受損及未受損造骨細胞之影響2009/08/012011/07/314000000
30981200908計畫主持人科技部探討不同藥物及載體對正常、受損及未受損造骨細胞之影響(1/3)2009/08/012012/07/311600000
40981200908計畫主持人科技部探討不同藥物及載體對正常、受損及未受損造骨細胞之影響2009/08/012012/07/314000000
50991201008計畫主持人科技部探討不同藥物及載體對正常、受損及未受損造骨細胞之影響(2/3)2010/08/012012/07/311300000
60992201105計畫主持人其他民間企業團體-其他基金(如基金會)荔枝廢棄物應用於機能性化妝保養品之開發計畫2011/05/012011/12/31150000
71001201108計畫主持人科技部探討不同藥物及載體對正常、受損及未受損造骨細胞之影響(3/3)2011/08/012012/07/311100000
81021201308計畫主持人科技部奈米遞送系統應用於退化性關節炎的治療2013/08/012014/07/31900000
91021201310計畫主持人其他民間企業團體-其他民間企業團體或個人八方燕燕窩應用於皮膚保養品之細胞活性評估2013/10/152014/10/14250000
101032201507計畫主持人科技部大專生研究計畫:以幾丁聚醣和縮水甘油基三甲基氯化銨途徑合成之N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) 對骨細胞新陳代謝之影響2015/07/012016/02/2948000
11104220162共同主持人行政院農業委員會農業試驗所嘉義農業試驗分所機能性水稻優質安全生產技術建立及加值產品研發2016/02/282016/11/301440000
121042201607計畫主持人科技部大專生計畫-改良幾丁聚醣衍生物N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride(HTCC)之合成方法及觀察對RAW264.7分化之蝕骨細胞的影響(吳依倫)2016/07/012017/02/2848000
131052201707計畫主持人科技部大專生計畫-蓼科植物萃取物抑菌活性及其應用潛力之研究(郭瑋倫)2017/07/012018/02/2848000
141061201709計畫主持人其他民間企業團體-其他民間企業團體或個人臺鹽樣品應用於軟骨保養之細胞活性評估2017/09/012018/08/31340000
151061201709計畫主持人其他民間企業團體-其他民間企業團體或個人使用常溫高壓均質法製備包覆菱角殼萃取物的固體脂質奈米粒子並測試其美白與抗皮膚老化之功效性2017/09/012018/08/31400000
161062201804計畫主持人行政院農業委員會農業試驗所嘉義農業試驗分所咖啡葉調節代謝症候群保健飲品原料之機能性分析與生物活性測試2018/04/182018/11/30372000
171071201901教育部108年度大專校院健康促進學校實施計畫2019/01/012019/12/31200000
181081201908科技部化學修飾幾丁聚醣並評估幾丁聚醣水溶性衍生物對退化性關節炎滑液膜纖維母細胞之影響2019/08/012020/07/31650000

學術活動(共計0筆)
序號學年度學期年度月份活動分類活動名稱活動地點/期刊學報/比賽名稱
11031201409學術期刊論文審查International Journal of Nanomedicine 
21031201412學術期刊論文審查International Journal of Nanomedicine 
31031201412學術期刊論文審查International Journal of Nanomedicine 
41032201503學術期刊論文審查International Journal of Nanomedicine 
51032201504學術期刊論文審查International Journal of Nanomedicine 
61032201507學術期刊論文審查International Journal of Nanomedicine 
71041201509學術期刊論文審查International Journal of Nanomedicine 
81041201509學術期刊論文審查International Journal of Nanomedicine 
91041201510學術期刊論文審查International Journal of Nanomedicine 
101042201603學術期刊論文審查International Journal of Nanomedicine 
111042201607學術期刊論文審查International Journal of Nanomedicine 

推廣工作(共計22筆)
序號學年度學期年度月份推廣類別推廣名稱推廣地點
11021201308輔導嘉義大學育成中心進駐廠商-台灣嘉農國際生物科技股份有限公司輔導老師  
21021201310輔導擔任102學年度生化科技系創意DNA模型競賽評審工作 
31022201406輔導103年度生命科學院第一屆學生學術研究成果優良海報評選競賽評審委員 
41022201406其他國立嘉義大學生化科技學系碩士班102學年度第2學期研究生郭鎮彰碩士學位考試委員會論文口試委員 
51022201406其他國立嘉義大學生化科技學系碩士班102學年度第2學期研究生張凱茜碩士學位考試委員會論文口試委員 
61022201406其他國立嘉義大學生化科技學系碩士班102學年度第2學期研究生陳奕文碩士學位考試委員會論文口試委員 
71022201406學術演講或教學講習主講協助102學年度長庚科技大學嘉義分部護理系「感染醫學生物標誌及臨床照護研究」研習活動講座長庚科技大學 
81022201407其他國立嘉義大學生化科技學系碩士班10ㄉ學年度第2學期研究生邱憲君碩士學位考試委員會論文口試委員 
91031201408輔導嘉義大學育成中心進駐廠商-台灣嘉農國際生物科技股份有限公司輔導老師  
101031201409其他國立嘉義大學生化科技學系碩士班103學年度第1學期研究生孫詩婷碩士學位考試委員會論文口試委員 
111031201410輔導擔任102學年度生化科技系創意DNA模型競賽評審工作 
121031201501輔導國立嘉義大學生化科技學系碩士班103學年度第1學期研究生蔡哲維碩士學位考試委員會論文口試委員 
131032201503其他103學年度第二學期博士班研究生學位考試考試委員 
141032201504輔導嘉義大學育成中心進駐廠商-子侯國際股份有限公司輔導老師 
151032201506其他國立嘉義大學應用化學系碩士班103學年度第2學期研究生鐘佩珊碩士學位考試委員會論文口試委員 
161032201506其他國立嘉義大學應用化學系碩士班103學年度第2學期研究生陳健儒碩士學位考試委員會論文口試委員 
171032201507輔導新加坡Agency for Science, Technology and Research (A* STAR) 研究計畫審查委員 
181041201508輔導Controlled Release and Drug Delivery Symposium 2015 海報審查委員 
191041201510輔導擔任104年嘉義市環保知識挑戰擂台賽裁判 
201042201606輔導擔任105年度生命科學院第三屆學生學術研究成果優良海報評選競賽評審委員 
211042201607其他國立嘉義大學生化科技學系碩士班104學年度第2學期研究生陳品璇碩士學位考試委員會論文口試委員 
221051201612其他國立嘉義大學生化科技學系碩士班105學年度第1學期研究生黎海健碩士學位考試委員會論文口試委員 
231052201705輔導嘉義大學育成中心進駐廠商-晁陽國際股份有限公司輔導老師 

其它(共計1筆)
序號學年度學期年度月份人員名稱題目(標題)其它
11031201411張心怡嘉義大學103年度獲選績優兼任行政工作教師嘉義大學103年度獲選績優兼任行政工作教師及職員