研究成果列表
單位名稱微生物免疫與生物藥學系教師姓名翁炳孫
教師分級教授專兼任專任
在校狀態在職行政職務

期刊論文(共計30筆)
序號學年度學期年度月份作者題目通訊作者作者順位期刊名稱卷數頁數關鍵字
1109220216翁炳孫Sulforaphane inhibits blue light-induced inflammation and apoptosis by upregulating the SIRT1/PGC-1α/Nrf2 pathway and autophagy in retinal pigment epithelium cells其他Toxicology and Applied Pharmacology421 1-11  
2108220206翁炳孫Carbon monoxide‑releasing molecules protect against blue light exposure and inflammation in retinal pigment epithelial cells其他International Journal of Molecular Medicine46 1096-1106.  
3106120181Chen LG, Zhang YQ, Wu ZZ, Hsieh CW, Chu CS, Wung BS.翁炳孫Peanut arachidin-1 enhances Nrf2-mediated protective mechanisms against TNF-α-induced ICAM-1 expression and NF-κB activation in endothelial cells.其他Int J Mol Med.41 541-547  
4106120178Liu YF, Hsieh CW, Chang YS, Wung BS.翁炳孫Effect of acetic acid on ethanol production by Zymomonas mobilis mutant strains through continuous adaptation.其他BMC Biotechnol.63  
5105220176Yang PM, Chen HZ, Huang YT, Hsieh CW, Wung BS.翁炳孫Lycopene inhibits NF-κB activation and adhesion molecule expression through Nrf2-mediated heme oxygenase-1 in endothelial cells.其他International Journal of Molecular Medicine39 1533-1450  
61051201612Yang PM, Huang Yu-Ting, Zhang YQ, Hsieh CW, 翁炳孫*Carbon monoxide releasing molecule induces endothelial nitric oxide synthase activation through a calcium and phosphatidylinositol 3-kinase/Akt mechanism其他Vascular Pharmacology87 209-218 Carbon monoxide • endothelial nitric oxide synthase • calcium • Akt 
7104220166翁炳孫Lycopene inhibits ICAM-1 expression and NF-κB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells其他Life Sciences155 94-101  
8102220147Yan-Chang Yang, Yu-Ting Huang, Chia-Wen Hsieh, Po-Min Yang, Being-Sun WungCarbon Monoxide Induces Heme Oxygenase-1 to Modulate STAT3 Activation in Endothelial Cells via S-Glutathionylation其他PLOS ONEe100677  
9102220145Po-Yen Yeh, Chia-Yu Li, Chia-Wen Hsieh, Yan-Chang Yang, Po-Min Yang and Being-Sun WungCO-releasing molecules and increased heme oxygenase-1 induce protein S-glutathionylation to modulate NF-κB activity in endothelial cells其他Free radical biology and medicine70 1-13  
10100220123Lin YC, Huang GD, Hsieh CW, and Wung BS*The glutathionylation of p65 modulates NF-κB activity in 15-Deoxy-D12,14D-prostaglandin J2-treated endothelial cells. 其他Free Radic. Biol. Med.52 1844-1853  
11099120111Chen CC, Chen HL, Hsieh CW, Yang YL and Wung BS* The upregulation of NF-E2-related factor-2-dependent glutathione by carnosol provokes a cytoprotective response and enhances cell survival.第一順位 Acta Pharmacologica Sinica   
120991201010Chen CC, Ke WH, Ceng LH, Hsieh CW and Wung BS* Calcium-and phosphatidylinositol 3-kinase/Akt-dependent activation of endothelial nitric oxide synthase by apigenin. 第一順位life Sci.    
13099120108Liao BC, Hsieh CW, Lin YC and Wung BS* The glutaredoxin/glutathione system modulates NF-κB activity by glutathionylation of p65 in cinnamaldehyde-treated endothelial cells.第一順位 Toxicol. Sci.    
14098120101Lian KC, Chuang JJ, Hsieh CW, Wung BS*, Huang GD, Jian TY, and Sun YW Dual mechanisms of NF-B inhibition in carnosol-treated endothelial cells.第一順位 Toxicol. Appl. Pharmacol.    
15097120091Wei YS, Wung BS, Lin YC, Hsieh CW* Isolating a cytoprotective compound from Ganoderma tsugae: effects on induction of Nrf-2-related genes in endothelial cells.第一順位 Biosci Biotechnol Biochem.   
160971200810Chen LG, Liu YC, Hsieh CW, Liao BC and Wung BS* The tannin 1--O-Galloylpunicalagin mediates calcium-dependent activation of endothelial nitric-oxide synthase involving phosphatidylinositol 3-kinase/Akt pathway in endothelial cells. 第一順位Mol. Nutr. Food Res. 52 1162-71  
17096120081Liu YC, Hsieh CW, Weng YC, Chuang SH, Hsieh CY and Wung BS* Sulforaphane inhibition of monocyte adhesion via the suppression of ICAM-1 and NF-B is dependent upon glutathione depletion in endothelial cells第一順位 Vasc. Pharmacol.    
18096120081Liao BC, Hsieh CW, Liu YC, Tzeng TT, Sun YW and Wung BS* Cinnamaldehyde inhibits the tumor necrosis factor-α-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-κB activation: effects upon IB and Nrf2.第一順位 Toxicol. Appl. Pharmacol.   
19095120071Liu YC, Hsieh CW, Wu CC and Wung BS*Chalcone inhibits the activation of NF-B and STAT3 in endothelial cells via endogenous electrophile.第一順位 life Sci.    
200951200610Lia PH, Sun YW, Hsieh CW, Wung BS*Upregulation of endothelial heme oxygenase-1 expression by non-toxicity concentrations of cinnamaldehyde.第一順位Food Sci. Agric. Chem.    
21095120068Wu CC, Hsieh CW, Lai PH, Lin JB, Liu YC and Wung BS*Upregulation of endothelial heme-oxygenase-1 expression through the activation of the JNK pathway by sublethal concentrations of acrolein.第一順位Toxicol. Appl. Pharmacol.   
22094120061Wung BS*, Hsu MC, Wu CC and Hsieh CWPiceatannol is a potent inducer of endothelial heme oxygenase-1 via novel protein kinase C and tyrosine kinase pathways.第一順位 Pharmacology. Research  Endothelial cells; Heme oxygenase-1; Piceatannol; Protein kinase C 
23094120061Wu CC, Hsu MC, Hsieh CW, Lin JB, Lai PH and Wung BS*Upregulation of heme oxygenase-1 by Epigallocatechin-3-gallate via the phosphatidylinositol 3-kinase/Akt and ERK pathways.其他 life Sci   
24094120061Wung BS*, Wu CC, Hsu MC, and Hsieh CW15-Deoxy-D12,14–prostaglandin J2 suppresses IL-6-induced STAT3 phosphorylation via electrophilic reactivity in endothelial cells.第一順位 life Sci.   
25093120051Wung BS*, Hsu MC., Wu CC. and CW HsiehResveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells via the inhibition of STAT3 phosphorylation.第一順位Life Sciences  Resveratrol• IL-6• intercellular adhesion molecule-1• STAT3 • endothelial cells 
26093120051Wung BS C. W. Ni and Wang DLInduction of ICAM-1 expression by TNFa and IL-6 is mediated by distinct pathway via Rac in endothelial cells.第一順位J. Biomed. Sci.   
27089120011Wung BS, Cheng JJ, Shyue SK and Wang DLNitric oxide modulates monocyte chemotactic protein-1 expression in endothelial cells under cyclic strain.第一順位Arterioscler. Thromb. Vasc. Biol.   
28089120011Cheng JJ, Wung BS, Chao YJ and Wang DLSequential Activation of Protein Kinase C-a and -e is Required for Cyclic Strain-Induced ERK1/2 Activity in Endothelial Cells.第二順位J. Biol. Chem.   
29089120011Chang YL, Shen JJ, Wung BS, Cheng JJ and Wang DLChinese herbal Remedy Wogonin inhibits monocytechemotactic prtein-1 gene expression in human endothelial cells.第三順位Mol. Pharmacol.   
30089120011Lo LW, Cheng JJ, Chiu JJ, Wung BS, and Wang DLHypoxia-induced early growthresponse-1 expression in endothelial cell involves the activation of PKC and Ras/Raf-1/ERK pathway.其他J. Cell. Physiol.   

會議論文(共計28筆)
序號學年度學期年度月份作者題目通訊作者作者順位發表性質會議論文集或研討會名稱地點
1110220223Yu-Han Wu, Wei-Han Deng, Yi-Zhen Chen and Being-Sun Wung*翁炳孫Kaempferol prevents against blue light-induced oxidative stress and mitochondrial apoptosis through PGC-1/Nrf2 pathway and autophagy in retinal pigment epithelial cells.其他壁報發表The 36th Joint Annual Conference of Biomedical Sciences  
21101202111翁炳孫Being-Sun Wung1, Shi-Yun Wang, Yung-Ni Lin and Yen-Tzu TsengProtective mechanism of sulforaphane on blue light-induced retinal cell damage through upregulating SIRT1/PGC-1alpha/Nrf2 pathway and autophagy.第一順位壁報發表14th Asia Pacific Federation of Pharmacologists, E094 Taipei, Taiwan, ROC, 2021. Taipei 
31091202010Shi-Yun Wang, Yung-Ni Lin, Yen-Tzu Tseng, Po-Min Yang and Being-Sun Wung翁炳孫Sulforaphane inhibits blue light-induced cell injury through autophagy and SIRT1/Nrf2 pathway in retinal pigment epithelium cells 其他壁報發表International Conference on Biotechnology and Healthcare, Chiayi, ROC  
4106220183An-Chen Ku, Shun Yang, Kai-Chein Su, Being-Sun Wung*翁炳孫GYY4137, a hydrogen sulfide donor, inhibits NF-κB signals by cell redox state in endothelial cells.其他壁報發表The 33rd Joint Annual Conference of Biomedical Sciences Taipei, Taiwan 
5106220183Shao-Ho Yuan, Tzu-Chiao Lan, Being-Sun Wung* 翁炳孫Protective Mechanisms of CO Releasing Molecules on Retinal Pigment Epithelial Cells against Inflammation.其他壁報發表The 33rd Joint Annual Conference of Biomedical Sciences Taipei, Taiwan 
6106120178翁炳孫he phytochemical-induced cytoprotective mechanism in endothelial cells.第一順位口頭發表International seminar on Medicinal Plant Biochemistry: Antibacterial and Cytotoxic Activity of Tropi 印尼 Bogor 
71051201611Being-Sun Wung*, Yuan-Chun Lin, and Being-Chyuan LiaoProtein S-glutathionylation as a phytochemical-induced cytoprotective mechanism in endothelial cells第三順位口頭發表第六屆 國際植物化合物暨疾病預防與功能評估研討會  
81051201611Yu-Qi Zhang , Zhi-Zhen Wu and Being-Sun Wung翁炳孫Lycopene inhibits ICAM-1 expression by Nrf2-regulated cell redox state in RPE cells. 第三順位壁報發表 第六屆 國際植物化合物暨疾病預防與功能評估研討會 嘉義大學 
9104220167翁炳孫 and Yu-Ting HuangCarbon Monoxide Donor in Endothelial Cells Mediates NO Synthesis via Intracellular Calcium and PI3/Akt-Dependent Signaling. 12nd International Congress of Cell Biology, 2016, 第一順位壁報發表12nd International Congress of Cell Biology  
101041201511張淯棋,吳致甄,翁炳孫*花生萃取物Arachidin-1對血管內皮細胞抗發炎機制。第三順位口頭發表第三屆大豆高加價值產品研發研討會  
11104120158YCYang, YT Huang, and Wung BS*CO-induced protein S-glutathionylation modulates STAT3 activation via heme-oxygenase-1 expression. 2015, Amsterdam, The Netherlands第三順位壁報發表17th INTERNATIONAL SYMPOSIUM ON ATHEROSCLEROSIS  
12102220147翁炳孫CO donors induce protein S-glutathionylation to modulate NF-κB activity through Heme-oxygenase-1 expression. 第一順位壁報發表17th World Congress on Basic and Clinical Pharmacology  
13102220144翁炳孫Carbon monoxide releasing molecules increase endothelial nitric oxide synthase activity第二順位壁報發表The 29th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, ROC  
14102220144翁炳孫The upregulation of Nrf-2-dependennt HO-1 by lycopene provokes an anti-inflammatory effect in endothelial cells第三順位壁報發表The 29th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, ROC  
150991201010Wung BS*, Lin YC, and Liao BCProtein S-glutathionylation as an anti-inflammatory strategy for vascular diseases.第一順位口頭發表8th Annual Congress of International Drug Discovery Science and Technology (IDDST) Beijing, China 
16098220107Wung BS Carnosol modulates NF-kB activity by dual mechanisms in endothelial cells. 16th World Congress on Basic and Clinical Pharmacology Copenhagen,  
17097220097Liao BC, and Wung BS The glutaredoxin/glutathione system modulates NF-κB activity by glutathionylation of p65 in cinnamaldehyde-treated endothelial cells.XV International Symposium of Atherosclerosis. Boston 
18097220094Ke WH, Ceng LH, Wung BSA flavonoid, apigenin induces the calcium-dependent activation of endothelial nitric-oxide synthase via the phosphatidylinositol 3-kinase/Akt pathway in endothelial cellsThe 24nd Joint Annual Conference of Biomedical Sciences Taipei, Taiwan 
19096220087Wung BS Cinnamaldehyde inhibits the tumor necrosis factor-α-induced expression of adhesion molecules in endothelial cells by suppressing NF-κB activation.Experimental Biology ,  San Diego,  
20095220074Liu YC and Wung BS Chalcone inhibits the activation of NF-κB and STAT3 in endothelial cells via endogenous electrophile.The 22nd Joint Annual Conference of Biomedical Sciences Taipei, Taiwan 
21095220074Wei YS, Hsieh CW, Wung BS, Lin YJ Upprgulation of NF-E2-related factor-2 expression by extracts of Ganoderma Tsugae in endothelial cellsThe 22nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan,  
22095220074Chen WY, Wung BS, Robin YY ChiouAnti-inflammatory activities of peanut arechidin-1 in human endothelial cellsThe 22nd Joint Annual Conference of Biomedical Sciences,  Taipei, Taiwan 
23093220057Hsu MC and Wung BS Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells via the inhibition of STAT3 phosphorylation.The 20th Joint Annual Conference of Biomedical Sciences Taipei, Taiwan 
24093220056Lai, P. H. and Wung BS. Upregulation of heme oxygenase-1 by Epigallocatechin-3-gallate via the phosphatidylinositol 3-kinase/Akt and ERK pathways. The 1st International Symposium on Phytochemicals: Bioactivity, Genomics, and Proteomics. Chiayi, Taiwan 
25093220056Liu YC, Hsieh CW, and Wung BSPiceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways.The 1st International Symposium on Phytochemicals: Bioactivity, Genomics, and Proteomics Chiayi, Taiwan 
26093220056Wu CC, and Wung BSResveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibition of STAT3 phosphorylation.The 1st International Symposium on Phytochemicals: Bioactivity, Genomics, and Proteomics Chiayi, Taiwan 
27093220056Wei YS, Wung BS, and Hsieh CWEthanol extracts of Ganoderma tsugae induced Hemooxygenase-1 expression in endothelial cell. The 1st International Symposium on Phytochemicals: Bioactivity, Genomics, and Proteomics Chiayi, Taiwan 
28093220054Wu CC and Wung BS 15-Deoxy-12,14–prostaglandin J2 suppresses IL-6-induced STAT3 phosphorylation via thiol depletion in endothelial cells The 20th Joint Annual Conference of Biomedical Sciences Taipei, Taiwan,  

研究計畫(共計32筆)
備註欄說明:「教師研究計畫管理系統轉入之計畫」(係指依「國立嘉義大學產學合作計畫實施要點」第3點規定,與政府機關、法人、公民營事業機構、民間團體、學術研究機構等合作辦理有關事項,以本校名義與合作機構辦理簽約,其經費撥入本校之產學合作計畫。)
序號學年度學期年度月份參與性質委辦單位計畫名稱開始日期結束日期經費備註欄
11122202407計畫主持人國家科學及技術委員會大專學生研究計畫大專生計畫:紅光誘導視網膜色素上皮細胞粒線體生合成與品質管控減緩飢餓造成的衰老-指導學生:黃宣軒2024/07/012025/02/2858,000教師研究計畫管理系統轉入之計畫
21112202307計畫主持人國家科學及技術委員會大專學生研究計畫大專生計畫:一氧化碳釋放劑,CORM-2,提高抗氧化和自噬對抗視網膜色素上皮細胞的細胞損傷2023/07/012024/02/2848,000教師研究計畫管理系統轉入之計畫
31112202307計畫主持人國家科學及技術委員會大專學生研究計畫大專生計畫:一氧化碳釋放劑,CORM-2,提高抗氧化和自噬對抗視網膜色素上皮細胞的細胞損傷-指導學生:蔡陞2023/07/012024/02/2948,000教師研究計畫管理系統轉入之計畫
41111202208計畫主持人國家科學及技術委員會硫化氫與內源性硫化氫在視網膜色素上皮細胞對抗細胞功能受損與血管新生的機轉2022/08/012023/07/311,340,000教師研究計畫管理系統轉入之計畫
51102202207計畫主持人國家科學及技術委員會大專學生研究計畫大專生計畫:在人類視網膜色素上皮細胞中GYY4137促進自噬和線粒體質量以對抗藍光誘導的細胞凋亡和細胞老化-指導學生:鍾佩琳2022/07/012023/02/2858,000教師研究計畫管理系統轉入之計畫
61081201908計畫主持人國家科學及技術委員會內皮細胞單硫醇基榖氧還蛋白對細胞壓力反應所扮演的角色2019/08/012020/07/311,359,000
71052201707計畫主持人國家科學及技術委員會大專生計畫-一氧化碳釋放劑對視網膜色素上皮細胞抗氧化壓力及抗發炎的保護機轉(籃子喬)2017/07/012018/02/2848,000
81052201707計畫主持人其他政府機關-其他政府單位生技產業人才培訓就業學程2017/07/012018/08/31750,000
91051201608計畫主持人國家科學及技術委員會含硫氫基抗氧化酵素榖氧還蛋白3在內皮細胞的保護機轉2016/08/012017/07/311,240,000
101041201508計畫主持人國家科學及技術委員會一氧化碳對血管內皮細胞的保護機制:蛋白質巰基修飾所扮演的角色(3/3)2015/08/012016/07/311,247,000
111031201408計畫主持人國家科學及技術委員會一氧化碳對血管內皮細胞的保護機制:蛋白質巰基修飾所扮演的角色(2/3)2014/08/012015/07/311,224,000
121021201308計畫主持人國家科學及技術委員會一氧化碳對血管內皮細胞的保護機制:蛋白質巰基修飾所扮演的角色2013/08/012016/07/313,637,000
131021201308計畫主持人國家科學及技術委員會一氧化碳對血管內皮細胞的保護機制:蛋白質巰基修飾所扮演的角色(1/3)2013/08/012014/07/311,166,000
141012201307計畫主持人國家科學及技術委員會大專生計畫-探討Lycopene對內皮細胞之抗發炎反應機轉2013/07/012014/02/2847,000
15100120121計畫主持人其他民間企業團體-其他基金(如基金會)應用富含伽瑪胺基丁酸(GABA)的乳酸發酵雜糧類機能素材之產品開發。2012/01/012012/12/310
161001201201計畫主持人其他民間企業團體-其他基金(如基金會)應用富含伽瑪胺基丁酸(GABA)的乳酸發酵雜糧類機能素材之產品開發2012/01/012012/12/31750,000
171001201108計畫主持人國家科學及技術委員會一氧化碳造成的蛋白質麩胱甘化做為內皮細胞抗發炎機制2011/08/012012/07/31760,000
18100120118計畫主持人國家科學及技術委員會一氧化碳造成的蛋白質麩胱甘?化做為內皮細胞抗發炎機制2011/08/012012/07/310
190992201107計畫主持人國家科學及技術委員會探討Carnosol誘導增加NO及其調控路徑機轉2011/07/012012/02/280
200992201107計畫主持人國家科學及技術委員會探討 p65 的麩胱甘?化對 NF-κB 活性之影響2011/07/012012/02/280
21099120111計畫主持人其他民間企業團體-其他基金(如基金會)開發富含伽瑪胺基丁酸(GABA)的雜糧類醱酵機能性計畫2011/01/012011/12/310
22099120108共同主持人國家科學及技術委員會整合雷射加熱與微流體系統在細胞選別與基因檢測平台之研究2010/08/012012/07/310
23097120088共同主持人國家科學及技術委員會探討大白鼠頭部外傷所引發之腦水腫現象中鈉鉀氯轉運蛋白所扮演之角色及其分子機轉.2008/08/012011/07/310
240971200808總計畫主持人國家科學及技術委員會GRX/GSH經由蛋白質glutathionylation調控內皮細胞發炎反應2008/08/012011/07/312,655,000
250962200804計畫主持人國家科學及技術委員會探討多酚類化合物促進內皮細胞一氧化氮產生2008/04/012008/12/310
26095220077共同主持人國家科學及技術委員會細胞貼附力量測系統之研發2007/08/012010/07/310
270952200704計畫主持人國家科學及技術委員會探討肉桂醛(Cinnamaldehyde)對於內皮細胞的抗發炎機轉2007/04/012007/12/310
280951200608總計畫主持人國家科學及技術委員會 植物化合物對內皮細胞保護作用的機轉2006/08/012007/07/31700,000
29092120041國家科學及技術委員會血管內皮細胞發炎反應的細胞與分子機制-發炎物質引起內皮細胞反應中Rho蛋白家族的角色(3)2004/08/012007/07/31900,000
30091120031國家科學及技術委員會NADPH氧化酶在內皮細胞傳訊上的角色2003/08/012004/07/31925,700
31090120021國家科學及技術委員會抑制Rho蛋白在內皮細胞抗發炎及抗動脈硬化上的作用2002/08/012003/07/311,179,400
32089120011國家科學及技術委員會發炎性細胞素經活化Racl訊號傳遞導致內皮細胞ICAM-1基因表現2001/08/012002/08/01669,600

專利(共計3筆)
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學術活動(共計9筆)
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4104220167出席國際研討會12nd International Congress of Cell Biology, Prague Czech Republic 
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151091202010輔導2020生物科技與健康產業國際研討會籌備委員 
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18108220204輔導長庚科技大學課程審查 
191081201911輔導學術期刊論文審查 
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21107220193輔導學術期刊論文審查 
22107120191輔導師大碩士班口試委員 
23107120188輔導學程課程審查 
24107120188輔導高雄大學生科系系教評委員 
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26106220184輔導教師升等著作審查 
27106120178輔導高雄大學生科系系教評委員 
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