◎系所教育目標：
教育目標：
本系以培養全方面的食品科技人才為目標，畢業生無論進入產官學研界都能發揮所學，為國家棟樑之材。
1. 有獨立思考及研發能力，可投入產官學研各領域服務。
2. 具有分析研判之學能與籌畫未來之遠見，能促進國家社會進步。
3. 具備所需之學養可從事更高深的學術研究 |
| ◎核心能力 | 關聯性 |
| 1.食品科學相關基礎知能 | 5 關聯性最強 |
| 2.具備食品科學實務能力 | 3 關聯性中等 |
| 3.獨立思考與創新能力 | 5 關聯性最強 |
| 4.溝通與領導能力 | 2 關聯性稍弱 |
| 5.食品科學結合人文關懷與全球意識 | 4 關聯性稍強 |
◎本學科內容概述：
瞭解人體內各營養素的合成分解調節等新陳代謝 |
◎本學科教學內容大綱：
瞭解生物體的新陳代謝與調控 |
◎本學科學習目標：
本課程為針對食品科學系同學開設生物化學之基礎課
課程目標為使學生熟悉生物分子之交互作用、化學反應、生物體之代謝及調節等基本專業知能，
以及具備生物化學研究之基本技能。 |
| ◎教學進度： |
| 週次 | 主題 | 教學內容 | 教學方法 |
01
| Introduction to metabolism (I) | 1. Metabolism is a network of reactions
2. Metabolic pathways
3. Major pathways in cells
4. Compartmentation and interorgan metabolism
5. Determination of the direction of metabolic reactions | 講授、討論。 |
02
| Introduction to metabolism (II) | 1. Free energy of ATP hydrolysis
2. Metabolic roles of ATP
3. Thioesters have high free energies of hydrolysis
4. Reduced coenzymes conserve energy from biological oxidations
5. Experimental methods for studying metabolism | 講授、討論。 |
03
| Glycolysis | 1. Enzymatic reactions of glycolysis
2. The ten steps of glycolysis
3. The fate of pyruvate | 講授、討論。 |
04
| Glycolysis / Pentose phosphate pathways | 1. Free energy changes in glycolysis
2. Regulation of glycolysis
3. Other sugars can enter glycolysis
4. The pentose phosphate pathways | 問題教學法、講授、討論。 |
05
| Gluconeogenesis, and glycogen metabolism | 1. Gluconeogenesis
2. Precursors for gluconeogenesis
3. Regulation of gluconeogenesis
4. Maintenance of glucose levels in mammals | 講授、討論。 |
06
| The citric acid cycle (I) | 1. Conversion of pyruvate to acetyl CoA
2. Citric acid cycle oxidizes acetyl CoA
3. Citric acid cycle enzymes
4. Entry of pyruvate into mitochondria | 講授、討論。 |
07
| Electron transport and ATP synthesis | 1. Overview of membrane-associated electron transport and ATP synthesis
2. The mitochondria
3. Chemisomotic theory and protonmotive force
4. Electron transport
5. Electron transport complexes | 講授、討論。 |
08
| 期中考 | 期中考 | 講授、討論、筆試。 |
09
| Lipid metabolism | Lipid metabolism | 問題教學法。 |
10
| Lipid metabolism | 1. Fatty acid synthesis
2. Synthesis of triacylglycerols and glycerophospholipids | 筆試。 |
11
| Lipid metabolism | 1.Synthesis of eicosanoids
4. Synthesis of ether lipids
5. Synthesis of sphingolipids
6. Synthesis of cholesterol | 講授、討論。 |
12
| Lipid metabolism | 1. Fatty acid oxidation
2. Regulation of lipid metabolism in mammals
3. Absorption and mobilization of fuel lipids
4. Ketone bodies are fuel molecules | 講授、討論。 |
13
| Amino acid metabolism (I) | 1. Nitrogen cycle and nitrogen fixation
2. Assimilation of ammonia
3. Synthesis of amino acids
4. Amino acids as metabolic precursors | 講授、討論。 |
14
| Amino acid metabolism | 1. Protein turnover
2. Amino acid catabolism
3. Urea cycle
4. Renal glutamine metabolism produces bicarbonate | 講授、討論、線上授課。 |
15
| Nucleotide Metabolism | 1 Synthesis of purine nucleotides
2. Synthesis of pyrimidine nucleotides
3. Salvage of purines and pyrimidines
4. Purine catabolism
5. Pyrimidine catabolism | 講授、討論、線上授課。 |
16
| 期末考週 | 期末考 | 筆試。 |
17
| 彈性教學週 | 彈性教學 | 討論。 |
18
| 彈性教學週 | 彈性教學 | 討論、筆試。 |
◎課程要求：
生物化學(I) |
◎成績考核
期中考50%
期末考50%
補充說明：教學大綱將依照校園行事曆以及修課人數作調整公布於課堂上。修定處於課堂公布。 |
◎參考書目與學習資源
Principles of Biochemistry 5th ed by Laurence A. Moran, Robert A. Horton, Gray Scrimgeour, and Marc Perry, Pearson Education Ltd. |
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