◎系所教育目標：
本系定位為發展農業生物科技，培養學生具生命科學和農業基礎知識，深入瞭解分子生物和生物技術的實際操作訓練，使學生成為學識與實務兼備的生物科技人才，著重於生物科技、作物科學、經濟動物、實驗動物和應用微生物的跨領域相關知識之整合，培養生物技術應用於農業之專業人才。 |
| ◎核心能力 | 關聯性 |
| 1.生物學相關專業知能 | 5 關聯性最強 |
| 2.生物技術相關專業知能 | 5 關聯性最強 |
| 3.農業科學相關專業知能 | 5 關聯性最強 |
| 4.具備結合生物技術之理論與基因操作能力等農業科學技術實作能力 | 5 關聯性最強 |
| 5.動植物基因轉殖和細胞組織培養能力等農業科學技術實作能力 | 4 關聯性稍強 |
| 6.跨領域生物技術、農業和生命科學知識、農業生態與環境保育能力 | 4 關聯性稍強 |
| 7.在地文化關懷與全球意識 | 3 關聯性中等 |
| 8.人文和自我反思、道德素養能力 | 3 關聯性中等 |
◎本學科內容概述：
由淺入深、完整介紹酵素化學的知識。 |
◎本學科教學內容大綱：
1.introduction.
2.functions and applications of enzymes.
3.compositions and structures of enzymes.
4.methods of studying enzymatic reactions.
5.characterizing enzymes.
6.enzyme kinetics.
7.factors influence enzyme activities.
8.enzymes-substrate interactions.
9.classification of enzymes.
10.oxidoreductases.
11.transferases.
12.hydrolases.
13.lyases.
14.isomerase.
15.ligases. |
◎本學科學習目標：
由淺入深、完整介紹酵素化學的知識。 |
| ◎教學進度： |
| 週次 | 主題 | 教學內容 | 教學方法 |
01
02/23 | introduction | scope of enzymology
textbook
criteria of grading score | 問題教學法、講授、討論。 |
02
03/02 | functions and applications of
enzymes | roles of enzymes and coenzymes in biosynthesis and
biotechnology
enzymes as targets for drug discovery | 問題教學法、講授、討論。 |
03
03/09 | compositions and structures of
enzymes | all enzymes are proteins
levels of protein structures
metallo-enzymes
glycoproteins | 問題教學法、講授、討論。 |
04
03/16 | methods of studying enzymatic
reactions | define enzymes' activities
methods of measuring enzyme activity
specific activity | 問題教學法、講授、討論。 |
05
03/23 | characterizing enzymes | methods of purifying enzymes
assays of protein concentration | 問題教學法、講授、討論。 |
06
03/30 | enzyme kinetics | procedure to study enzyme kinetics | 問題教學法、講授、討論。 |
07
04/06 | factors influence enzyme
activities | temperature
pH
activators
inhibitors
cofactors | 問題教學法、講授、討論。 |
08
04/13 | enzymes-substrate interactions | electrostatic interactions
hydrogen bonding
non-polar (Van der Waals) interactions
hydrophilic interactions | 問題教學法、講授、討論。 |
09
04/20 | 期中考 | 期中考 | 期中考。 |
10
04/27 | classification of enzymes (1) | oxidoreductases
transferases
hydrolases | 問題教學法、講授、討論。 |
11
05/04 | classification of enzymes (2) | lyases
isomerase
ligases | 問題教學法、講授、討論。 |
12
05/11 | oxidoreductases | introduction
mechanisms of enzymatic catalysis
examples
applications
conclusion | 問題教學法、口頭報告、講授、討論。 |
13
05/18 | transferases | introduction
mechanisms of enzymatic catalysis
examples
applications
conclusion | 問題教學法、口頭報告、講授、討論。 |
14
05/25 | hydrolases | introduction
mechanisms of enzymatic catalysis
examples
applications
conclusion | 問題教學法、口頭報告、講授、討論。 |
15
06/01 | lyases | introduction
mechanisms of enzymatic catalysis
examples
applications
conclusion | 問題教學法、口頭報告、講授、討論。 |
16
06/08 | isomerase | introduction
mechanisms of enzymatic catalysis
examples
applications
conclusion | 問題教學法、口頭報告、講授、討論。 |
17
06/15 | ligases | introduction
mechanisms of enzymatic catalysis
examples
applications
conclusion | 問題教學法、口頭報告、講授、討論。 |
18
06/22 | 期末考 | 期末考 | 期末考。 |
◎課程要求：
使學生能瞭解酵素之組成、結構、運作、應用原理、與方法。 |
◎成績考核
小考40%
期末考60%
|
◎參考書目與學習資源
1. Introduction to Enzyme and Coenzyme Chemistry, 2nd edition, Tim Bugg, Blackwell Publishing.
2. Lehninger’s Principles of Biochemistry, 4th ed., D.L. Nelson and M.M. Cox, Worth Publishers.
3. Biochemistry, 6th ed., J.M. Berg, J.L. Tymoczko, and L. Stryer, W. H. Freeman and company. |
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